Studies and Registries

Studies and Registries

DCRI Trials and Their Impact

Leading with science is at the core of every trial the DCRI designs and implements and every collaboration we undertake. Finding what’s next drives our work every day. Since 1996, the DCRI has disseminated more than 10,000 publications; our findings have been cited in more than 400,000 scientific articles. In 2016 alone, we collaborated with more than 4,750 co-authors from 1,521 institutions in 64 countries on more than 1,099 publications in 190 in top-tier journals. We are recognized as having one of the most collaborative environments within the clinical research market--academic and commercial. Together, with our longstanding academic-government partnerships, sponsor collaborations, and investigator relationships, we  ensure that evidence moves forward, facilitating change through the science that has a measurable impact on patients' lives.

Selected Trials and Registries

Trial/Registry Study Completed (published?) Primary Results Publication
GUSTO 1993 New
England Journal of Medicine
ESSENCE 1997 New England
Journal of Medicine
GUSTO IIB 1997 New England Journal
of Medicine
GUSTO III 1997 New England Journal
of Medicine
PURSUIT 1998 New England
Journal of Medicine
ASSENT-1 1999 American Heart
Journal
ASSENT-2 1999 Lancet
SYMPHONY 2000 Lancet
ASSENT-3 2001 Lancet
GUSTO IV-ACS 2001 Lancet
Second SYMPHONY 2001 Circulation
Val-HeFt 2001 New England
Journal of Medicine
Hypericum 2002 JAMA
PARAGON-B 2002 Circulation
SADHEART 2002 JAMA
XaNADU-ACS 2002 Circulation
PREVENT 2003 New England
Journal of Medicine
VALIANT Trial 2003 New England
Journal of Medicine
CRUSADE Registry 2004 JAMA
SYNERGY 2004 JAMA
SCD-HEFT EQOL 2005 New England
Journal of Medicine
VALIANT Registry 2005 European Heart
Journal
ASSENT-4 PCI 2006 Lancet
CHOIR 2006 New
England Journal of Medicine
ESPRIT 2006 Lancet
STS Registry 2007 Circulation
APEX-AMI 2009 European
Heart Journal
APPRAISE 2009 Circulation
EARLY ACS 2009 New
England Journal of Medicine
EMINENCE 2010 Circulation
NAVIGATOR 2010 New
England Journal of Medicine

New
England Journal of Medicine
REVERSAL-PCI 2010 Circulation
APPRAISE-2 2011 New England
Journal of Medicine
ARISTOTLE 2011 New England
Journal of Medicine
ASCEND-HF 2011 New England
Journal of Medicine
CRISP AMI 2011 JAMA
PROTECT 2011 JACC
REVEAL 2011 JAMA
ROCKET AF 2011 New England
Journal of Medicine
STICH 2011 New England
Journal of Medicine
TRACER 2011 New England
Journal of Medicine
INNOVATE-PCI 2012 Circulation: Cardiovascular Interventions
TRILOGY-ACS 2012 New England
Journal of Medicine
ORBIT-AF 2013 American Heart
Journal
RACE 2013 Circulation
RADAR 2013 European Heart
Journal
RECORD 2013 American Heart
Journal
REMIT 2013 JAMA
MILLION HEARTS 2014 American
Heart Journal
SAFE-PCI for Women 2014 JACC Cardiovascular Interventions
SOLSTICE 2014 Lancet
STABILITY 2014 New
England Journal of Medicine
BRIDGE 2015 New England
Journal of Medicine
IMPROVE-IT 2015 New England
Journal of Medicine
PLATFORM 2015 European Heart
Journal
PROMISE 2015 New England
Journal of Medicine
TECOS 2015 New England
Journal of Medicine
TRANSLATE-ACS 2015 Circulation
NHLBI Heart Failure Clinical Research Network 2016 JAMA
REGULATE-PCI 2016 Lancet
STICHES 2016 New England
Journal of Medicine
TVT Registry 2016 Circulation:
Cardiovascular Quality and Outcomes
VIVID 2016 Circulation