Neurosciences Medicine

Neurosciences Medicine

From epilepsy to depression to Alzheimer’s, neurological conditions affect almost everyone. And people are desperately seeking solutions for themselves or someone they love. The Neurosciences Medicine (NSM) research program at the DCRI is dedicated to taking bold action to find these solutions.

Boldly Answering Today's
Neuroscience Challenges

Driven by more than 40 psychiatry and neurology faculty, our program develops, conducts, and supports innovative phase I–IV clinical trials addressing neurological and psychiatric conditions for child, adolescent, adult, and geriatric patient populations.

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Research Highlights

Welsh-Bohmer to Lead Alzheimer’s Trials

Trained as a neuropsychologist, new DCRI faculty member Kathleen Welsh-Bohmer, PhD, focuses on prevention and treatment strategies to delay the onset of cognitive disorders occurring later in life.

New Digital Treatment
for ADHD

A new study led by the DCRI's Scott Kollins, PhD, suggests a digital treatment in the form of a video game specifically designed to improve attention could hold potential as a future treatment for the condition.

A New Model to Predict Alzheimer’s Progression

DCRI’s Sheng Luo, PhD and his co-authors have found that the novel combination of baseline information and longitudinal profiles of multiple clinical and neuroimaging markers can more accurately predict a patient's progression to Alzheimer’s disease.

  • Danny Laskowitz Profile
  • Richard Keefe, PhD Neurosciences Profile
  • Scott Kollins Profile
  • Sheng Luo on Predictive Modeling in Alzheimer's Disease

Innovations

  • Rapid-start site network for neurosciences trials
  • Biomarker development
  • Cognitive endpoint design and assessment in clinical trials
  • Control intervention development
  • FAST-FAIL trial methodology
  • Inpatient ICU trials (TBI)
  • Neuroimmunology biomarker imaging studies
  • Novel trial designs
  • RDOC-based research

Comprehensive Experience in Neuroscience Research

We conduct industry and government-funded clinical projects of all sizes covering the full spectrum of neurosciences disorders, featuring projects in psychiatry and neurology for child, adolescent, adult, and geriatric patient populations.

Our research interests and capabilities are wide-ranging and include a focus on ADHD, autism, mood and anxiety disorders, epilepsy, sleep disorders, neuromuscular disorders, stroke, and neurodegenerative diseases. Our capabilities include:

  • Early-phase PK/PD and POC trials, conducted in our onsite phase I unit
  • Game and device/sham-controlled trial design and conduct
  • Pediatrics (microdosing, PK)
  • Neurocritical care trials
  • Electroencephalography
  • Polysomnography
  • Nerve conduction studies and electromyography
  • Neuroimaging
  • Immune monitoring: mechanistic and predictive biomarkers
  • Translational studies
  • Large multisite trials
  • Full-service CRO activities (protocol design/development, data management, biostatistics, pharmacokinetics, site management/monitoring)

Neurosciences Medicine
Leadership at the DCRI

Daniel Laskowitz, MD, MHS, Director

Daniel LaskowitzDaniel Laskowitz graduated from the Duke University School of Medicine. After completing his residency at Hospital of the University of Pennsylvania, he returned to Duke to complete his residency in cerebrovascular disease and neurocritical care.

Laskowitz's research interests include exploring new therapeutic interventions in the clinical setting of stroke, intracranial hemorrhage, and closed head injury. He is committed to translational research, and has several active clinical research protocols designed to bring the research performed in the Multidisciplinary Research Laboratories to the clinical arena.

DCRI Neurosciences Medicine Faculty