DCRI Newsletter

DCRI Newsletter

DCRI newsletters highlight areas in which our faculty and clinical operations experts are engaged in cutting-edge research. Learn how we are helping to advance pragmatic clinical trials, leverage electronic health records, open data to researchers worldwide, drive mobile health, and usher in a new era of precision medicine.

Spring 2019

Welcome from Schuyler Jones, MD

At the DCRI, we are leading the way forward in conducting large pragmatic trials to answer important questions that impact patient care. A DCRI team recently finished enrollment for ADAPTABLE, the first pragmatic clinical trial conducted through PCORnet. One of the reasons this is so exciting is that the study is truly embedded in the health care system, and leverages data already collected in patients’ electronic health records.

ADAPTABLE will generate evidence that will inform the most effective dose of aspirin for individuals with heart disease, building on DCRI’s tradition of leading studies that improve clinical care. Another example of this legacy is ARISTOTLE, which was recently honored as a study that has changed practice. In this edition of the DCRI newsletter, you will also find other promising developments, such as an update on ECHO, a program coordinated through the DCRI that will examine early influences on child health outcomes.

We invite you to explore our newsletter to learn more about what is happening across the DCRI.

Schuyler Jones, MD
Assistant Professor of Medicine
Associate Professor in Population Health Sciences
Duke Clinical Research Institute

Using Real World Evidence to Make Discoveries

ADAPTABLE, a large pragmatic clinical trial being conducted by a DCRI team, recently reached its enrollment goal of 15,000 participants. Now, as the study moves into the data collection phase, study researchers will collect real world-evidence (RWE) from patients’ electronic health records.

But the study isn’t the only way the DCRI is making strides in the use of RWE. DCRI’s insights informed the FDA’s Framework for Real World Evidence, and current projects, such as the Clinical Trials Transformation Initiative (CTTI), continue to bolster DCRI’s reputation as a thought leader in the world of RWE.

Recent Awards

DCRI's ARISTOTLE study was honored as practice-changing by the New England Journal of Medicine.

DCRI receives CRO Leadership Award for fourth year with recognition in five categories.

David Leiman, MD, MSHP, was selected as one of 18 participants in this year's American Gastroenterological Association Future Leaders Program.

Duke University ranked 9th in the nation for federal medical research funding and was the largest recipient of NIH grant funding in North Carolina.

2019CoChiefFellows

Meet the 2019-20 DCRI Co-Chief Fellows

The newly selected co-chief fellows, Anna Hung, PhD, and Adam Nelson, MD, discuss what they’ve learned from their first year of fellowship, as well as their visions for the next academic year as they help to shape the DCRI Fellowship Program for a group of fellows from diverse therapeutic areas and research interests.

Recent DCRI News

Lack of physician guidance, fear of side effects lead to lower statin adherence

Despite national guidelines indicating that statins can lower risk of heart attack and stroke, many patients who could benefit do not take them. More than half of eligible patients say they were never offered the cholesterol-lowering drugs; the experience of or fear of side effects were reasons for stopping or refusing statins, according to new research by Duke and DCRI researchers in Journal of the American Heart Association.

Organizations join forces to create global alliance against antibiotic resistance

The U.S.-based Antibacterial Resistance Leadership Group (ARLG), part of the DCRI, and the University Medical Center (UMC) Utrecht, the managing entity of the COMBACTE (Combatting Bacterial Resistance in Europe) consortium, will work together to solidify a comprehensive global community to combat the threat of antibiotic resistance around the world.

ECHO program set to begin expansive child health research

The National Institutes of Health’s (NIH’s) ECHO Program has received single Institutional Review Board (sIRB) approval for its ECHO-wide Cohort Data Collection Protocol, clearing the program to start answering high-impact research questions related to early influences on child health outcomes. The DCRI serves as ECHO program’s coordinating center.

Few treatment guidelines for heart disease are based on rigorous study

Less than 10 percent of the treatment recommendations U.S. doctors rely on to manage care for heart patients are based on evidence gained from multiple large, randomized clinical trials — the gold standard for obtaining scientific data. The latest study, led by the DCRI, appeared in the Journal of the American Medical Association (JAMA).

New professional development program aims to advance women’s clinical research careers

Several DCRI faculty members are working with the American College of Cardiology to form a new professional development Clinical Trials Research Program which will provide training and networking to early- to mid-career female clinical research cardiologists who have been nominated by their institution to develop their research leadership skills further.

ACC.19 Scientific Sessions Roundup

During the March 16-18, 2019 American College of Cardiology Scientific Sessions in New Orleans, the DCRI's faculty and fellows participated in 183 events, including:

  • 16 Late Breaker Participants
  • 14 Special Sessions
  • 68 Chairs, Panelists, Presenters
  • 82 Posters

The DCRI-led ADAPTABLE Study also hosted a meet-and-greet session with study experts and a patient participant where they discussed the successes and learned experiences of a patient-centered pragmatic clinical trial.

Discover More About the DCRI

At the DCRI, we use knowledge gained from our clinical research to transform patient care. By sharing our perspective, our thought leaders advance the conversation around cutting-edge research in a variety of therapeutic areas and health care trends. We invite you to learn more about our perspective by exploring a collection of regularly updated videos, articles, and insights.

Everything we do at the DCRI is based on collaboration and the sharing of knowledge. Our researchers and operational teams work closely with each other, with our colleagues from the wider world of Duke University and Duke Health, and with our peers and partners around the world. View upcoming events featuring our thought leadership and opportunities for collaboration.