Matthew Roe

Matt Roe

Matthew T. Roe, MD, MHS

Faculty Director, Global Outcomes Commercial MegaTrials
DCRI Fellowship Program Director
Professor of Medicine



Dr. Roe received his medical degree and his Masters of Health Sciences in Clinical Research from Duke University School of Medicine. He completed an internal medicine residency at Duke University Medical Center and a cardiovascular fellowship at the Cleveland Clinic Foundation. Roe is a professor of medicine, with tenure, in the division of cardiovascular medicine.

Roe is the faculty director of the DCRI Global Outcomes Commercial MegaTrials group and has participated in the leadership and conduct of numerous clinical trials focused on therapies for acute coronary syndromes and chronic cardiovascular disease, including dal-OUTCOMES-2, TRILOGY-ACS, and ODYSSEY Outcomes. He has a keen interest in the operational conduct of clinical trials, and in the national and global academic collaborations that are critical to the successful execution of clinical trials.

Roe has served as the principal investigator for numerous clinical trials investigating anti-platelet therapies for acute myocardial infarction (MI), as well as myocardial protection agents for patients with acute ST-elevation MI. Additionally, Roe served as the co-principal investigator for the CRUSADE national quality improvement initiative performed at almost 500 hospitals in the U.S. from 2001-2006. Roe is the previous chair of the Research and Publications Sub-Committee for the American College of Cardiology (ACC) ACTION Registry-GWTG program evaluating care patterns for patients with acute MI. Roe serves as a member of the ACC National Cardiovascular Data Registry Scientific Oversight Committee and the American Heart Association (AHA) Mission Lifeline Scientific Task Force. Finally, Roe has been the DCRI principal investigator for the Data Analytic Center activities for the ACC-NCDR Cath PCI Registry, the ACTION Registry-GWTG Program, and the AHA Mission Lifeline program.

Roe serves as the director of the DCRI’s Research Fellowship Training Program and has contributed to the expansion of the DCRI fellowship program to more than 30 fellows per year. Roe supervises the faculty mentorship program for the DCRI research fellows and in 2008 won the Robert M. Califf Mentorship Award. Additionally, Roe served as the Fellowship Director for the AHA Pharmaceutical Roundtable Outcomes Research Grant for the DCRI Outcomes Research Center.