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Therapeutic Areas

Neurosciences Medicine

The DCRI is dedicated to advancing clinical research by promoting education, knowledge-sharing, scientifically designed studies, and operationally efficient clinical trial conduct. The DCRI's Neurosciences Medicine Research Program, comprising more than 40 psychiatry and neurology faculty, supports this mission through innovative programs, vast expertise across multiple disciplines, and broad-reaching influence as leaders in academic, industry, and government roles.

We conduct industry and government-funded clinical projects of all sizes covering the full spectrum of NSM disorders, featuring projects in psychiatry, neurology and analgesia, for child, adolescent, adult, and geriatric patient populations. Our research interests are wide-ranging and relevant, with a focus on ADHD, autism, mood and anxiety disorders, epilepsy, sleep disorders, stroke, and neurodegenerative diseases.

Recent Experience

Our program has enrolled more than 33,000 patients at 1,100 sites in 25 trials spanning all study phases, from animal models through post-market, a literal one-stop shop for NSM drug development.


  • Rapid-Start Site Network for Neurosciences Trials
  • Biomarker Development
  • Cognitive Endpoint Design and Assessment in Clinical Trials
  • Control Intervention Development
  • FAST-FAIL Trial Methodology
  • Inpatient ICU Trials (TBI)
  • Neuroimmunology Biomarker Imaging Studies
  • Novel Trial Designs
  • RDOC-Based Research


  • Early Phase PK/PD and POC Trials, conducted in our onsite Phase I unit
  • Game & Device/Sham-Controlled Trial Design and Conduct
  • Pediatrics (Microdosing, PK)
  • Neurocritical Care Trials
  • Electroencephalography
  • Polysomnography
  • Nerve conduction studies and electromyography
  • Neuroimaging
  • Immune monitoring – mechanistic and predictive biomarkers
  • Translational studies
  • Large multi-site trials
  • Full-service CRO activities (Protocol Design/Development, Data Management, Biostatistics, Pharmacokinetics, Site Management/Monitoring)


Our Neuroscience experts have been to the FDA many times for market approvals in drug, device, and diagnostic studies and are instrumental in creating and implementing new NIMH guidelines. Our faculty have published their research in major peer-reviewed journals and regularly present at national meetings, sharing knowledge and contributing to the formation of practice-changing innovations for tomorrow’s medicine.

Our Investigator Networks

The DCRI hosts investigator networks for child and adolescent psychiatry, including:

  • National Child Traumatic Stress Network, a nationwide consortium of premier research institutes, hospitals, and healthcare providers focused on improving the care of traumatized children.
  • Child and Adolescent Psychiatry Trials Network (CAPTN), the first consortium of its kind focused on pediatric psychopharmacology.
  • Treatment for Adolescents with Depression Study (TADS).
  • Mid Southern Primary Care Node of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN). Partners includes investigators from Duke, UNC Chapel Hill, Vanderbilt University, and the Carolinas HealthCare System.

Research Expertise:

  • ADHD
  • Aggression
  • Alzheimer’s / Dementias
  • Anxiety disorders
  • Autism
  • Bipolar disorders
  • Devices
  • Eating disorders
  • Epilepsy
  • Major depression
  • Multiple Sclerosis
  • Neurocognition
  • Neuromuscular disorders
  • Obesity
  • Tourette Syndrome / Obsessive Compulsive Disorder
  • Pain
  • Parkinson's disease
  • Schizophrenia
  • Sleep disorders
  • Substance abuse
  • Stroke
  • Traumatic Brain Injury


Faculty Director: Andrew Krystal, MD, MS 

Business Development Contact: Jenn Hart

Operations Contact: Maureen Cunningham


Our Scientific Experts:

Andrew Krystal, MD, MS
Professor, Psychiatry and Behavioral Sciences
Faculty Director, DCRI Neurosciences Medicine

Linmarie Sikich, MD
Psychiatry and Behavioral Sciences
Associate Director, Duke Center for Autism and Brain Development

Daniel Laskowitz, MD, MHS
Professor, Neurology
Professor, Neurobiology
Professor, Anesthesiology
Director, Neurovascular Laboratories

Scott Kollins, PhD, MS
Associate Professor, Medical Psychology
Professor, Psychiatry and Behavioral Sciences
Professor, Psychology and Neuroscience
Vice-Chair for Research Strategy and Development
Director, Duke ADHD Program

Rich Keefe, PhD
Professor, Psychiatry and Behavioral Sciences
Professor, Psychology and Neuroscience

Brad Kolls, MD, MMCi
Assistant Professor, Neurology

Jeffrey Guptill, MD, MA, MHS
Assistant Professor, Neurology
Associate Director, Duke Clinical Research Unit

Li-Tzy Wu, ScD, RN, MA
Professor, Psychiatry and Behavioral Sciences
Contact Node Principal Investigator and Director
Mid Southern Primary Care Node, National Drug Abuse Treatment Clinical Trials Network

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