Neurosciences Medicine

Neurosciences Medicine

neurosicencesFrom epilepsy to depression to Alzheimer’s, neurological conditions affect almost everyone. And people are desperately seeking solutions for themselves or someone they love. The Neurosciences Medicine (NSM) research program at the DCRI is dedicated to taking bold action to find these solutions.

Comprehensive Experience in Neuroscience Research

We conduct industry- and government-funded clinical projects of all sizes.

  • ADHD
  • Aggression
  • Alzheimer’s/dementias
  • Anxiety disorders
  • Autism
  • Bipolar disorders
  • Devices
  • Eating disorders
  • Epilepsy
  • Major depression
  • Multiple sclerosis
  • Neurocognition
  • Neuromuscular disorders
  • Obesity
  • Tourette syndrome/obsessive-compulsive disorder
  • Pain
  • Parkinson's disease
  • Schizophrenia
  • Sleep disorders
  • Substance abuse
  • Stroke
  • Traumatic brain injury
Trial/Study Experience
  • Early-phase PK/PD and POC trials, conducted in our onsite phase I unit
  • Game and device/sham-controlled trial design and conduct
  • Pediatrics (microdosing, PK)
  • Neurocritical care trials
  • Electroencephalography
  • Polysomnography
  • Nerve conduction studies and electromyography
  • Neuroimaging
  • Immune monitoring: mechanistic and predictive biomarkers
  • Translational studies
  • Large multisite trials
  • Full-service CRO activities (protocol design/development, data management, biostatistics, pharmacokinetics, site management/monitoring)
  • Rapid-start site network for neurosciences trials
  • Biomarker development
  • Cognitive endpoint design and assessment in clinical trials
  • Control intervention development
  • FAST-FAIL trial methodology
  • Inpatient ICU trials (TBI)
  • Neuroimmunology biomarker imaging studies
  • Novel trial designs
  • RDOC-based research

We Take Bold Steps in Neuroscience Medicine, Because Bold Solutions Are Needed

Driven by more than 40 psychiatry and neurology faculty, our program develops, conducts, and supports innovative phase I–IV clinical trials addressing neurological and psychiatric conditions for child, adolescent, adult, and geriatric patient populations.

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Neurosciences Medicine Leadership

Andrew Krystal, MD, MS, Co-Director,
Neurosciences Medicine

Andrew Krystal

Andrew D. Krystal, MD, MS, is director of the DCRI’s Neurosciences Medicine Research Program, Krystal links multi center clinical trial expertise and resources with the strong translational neuroscience and intervention-development research capabilities of Duke University’s Department of Psychiatry and Behavioral Sciences. In addition to being a professor in that department, Krystal also serves as the director of the Duke Sleep Research Program and clinical director of the Brain Stimulation Program.

Daniel Laskowitz, MD, MHS, Co-Director, Neurosciences Medicine

Daniel Laskowitz landscapeDaniel Laskowitz, MD, MHS, graduated from the Duke University School of Medicine. After completing his residency at Hospital of the University of Pennsylvania, he returned to Duke to complete his residency in cerebrovascular disease and neurocritical care. Laskowitz's research interests include exploring new therapeutic interventions in the clinical setting of stroke, intracranial hemorrhage, and closed head injury. He is committed to translational research, and has several active clinical research protocols designed to bring the research performed in the Multidisciplinary Research Laboratories to the clinical arena.

Faculty Profile: Richard Keefe, PhD

Richard Keefe video

Richard Keefe, PhD, discusses his work on cognitive impairment in patients with schizophrenia.

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DCRI-Hosted Investigator Networks for Child and Adolescent Psychiatry

  • National Child Traumatic Stress Network: A nationwide consortium of premier research institutes, hospitals, and healthcare providers focused on improving the care of traumatized children.
  • Child and Adolescent Psychiatry Trials Network (CAPTN): The first consortium of its kind focused on pediatric psychopharmacology.
  • Treatment for Adolescents with Depression Study (TADS)
  • Mid Southern Primary Care Node of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN): Partners include investigators from Duke, UNC-Chapel Hill, Vanderbilt University, and the Carolinas HealthCare System.