PRagmatic Evaluation of Events and Benefits of Lipid Lowering in Older Adults

About the Study

Currently Recruiting: Participants

Study Drug/Intervention: Atorvastatin 40mg or matching placebo

Study Timeline: This study is expected to conclude in December 2026.

Visit the Study Website ID: NCT04262206



  • To determine if statins will reduce the occurrence of the composite of death, dementia, and persistent disability in community-dwelling older adults without cardiovascular disease (CVD) or dementia at baseline.
  • To determine if statins will reduce the occurrence of the co-secondary composites of MCI or dementia and CV composite outcome.

Participation Criteria

Age 75 years or older without prior MI or stroke, without dementia, and not currently taking a statin but able to take one.

Telesite Enrollment

Participants can enroll through Duke Telesite by phone from anywhere in the country, and do not need to be a patient at a physical site. The Telesite enrollment supports both English and Spanish speaking participants from anywhere in the United States, including Puerto Rico. Call 833-385-3899 for more information about enrollment in PREVENTABLE.


National Institute on Aging and National Heart Lung Blood Institute (NIA/NHLBI)

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