Collaboration among research sites, community partners, patients, their caregivers, and our study teams is critical to addressing current medical care challenges. We work with institutions around the world that are equally committed to safe, inclusive, and efficient clinical research.
We have provided a list of current opportunities for research partners and participants to engage with the DCRI, organized by therapeutic topic. By clicking on the study name, you can learn more about each opportunity.
Additional Resources for Patients and Study Participants
- Clinical Trials at Duke website: clinical trials available through Duke Health.
- ClinicalTrials.gov: a database of privately and publicly funded clinical studies conducted around the world.
Cardiology
- ARTEMIS: A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
- BALANCED-HF: A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function
- PREVENTABLE: PRagmatic Evaluation of Events and Benefits of Lipid Lowering in Older Adults
- SPIRRIT- HFpEF: Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction
COVID-19
- ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications
- HERO-Together Boost
- RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
- RECOVER VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Hepatology
- PAL-Liver: Introducing Palliative Care (PC) within the Treatment of End Stage Liver Disease (ESLD): A Cluster Randomized Controlled Trial
Musculoskeletal
- SKOAP: A sequenced-strategy for improving outcomes in people with knee osteoarthritis pain
Other Drug/Treatment Evaluations
- POSITIVE: Integrated Treatment for Veterans with Co-Occurring Chronic Pain and Opioid Use Disorder
- KALPAS: Optimizing the use of ketamine to reduce chronic postsurgical pain: Ketamine Analgesia for Long-lasting Pain After Surgery
- MTH02: Pharmacokinetics, Pharmacodynamics, and Safety of a Single Dose Intravenous Methadone in Healthy Adult Volunteers
Pediatric
Cardiology
- Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension
Pharmacokinetics
- CUDDLE: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children per Standard of Care
- SIL02: Safety of Sildenafil in Premature Infants
Rheumatology
- CARRA Registry: Observational Study of Pediatric Rheumatic Diseases
Surgery
- ANA: Anesthetics and Analgesics in Children
- SurgeryPal: Effectiveness of an mHealth psychosocial intervention to prevent transition from acute to chronic postsurgical pain in adolescents
Respiratory
- TBS02: A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults with Asthma