Collaboration among research sites, community partners, patients, their caregivers, and our study teams is critical to addressing current medical care challenges. We work with institutions around the world that are equally committed to safe, inclusive, and efficient clinical research.
We have provided a list of current opportunities for research partners and participants to engage with the DCRI, organized by therapeutic topic. By clicking on the study name, you can learn more about each opportunity.
Additional Resources for Patients and Study Participants
- Clinical Trials at Duke website: clinical trials available through Duke Health.
- ClinicalTrials.gov: a database of privately and publicly funded clinical studies conducted around the world.
Cardiology
- ARTEMIS: A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
- BALANCED-HF: A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function
- COMET-HF: CY 1033 A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Trial to Assess Efficacy and Safety of Omecamtiv Mecarbil in Patients with Symptomatic Heart Failure with Severely Reduced Ejection Fraction
- IMPROVE-AD: IMPRoving Outcomes in Vascular DisEase- Aortic Dissection
- POSIBIL6: Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis
- PREVENTABLE: PRagmatic Evaluation of Events and Benefits of Lipid Lowering in Older Adults
- Test 2 Treat: A Randomized Implementation Trial to Improve LDL-C Management after Hospitalization for ASCVD
- V-INCLUSION: Evaluating INClisiran as a soLUtion to improve LDL-C management and cloSe care gaps in an Inclusive ASCVD and ASCVD risk equivalent populatiON (VICTORION-INCLUSION)
COVID-19
- RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection
- RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Hepatology
- PAL-Liver: Introducing Palliative Care (PC) within the Treatment of End Stage Liver Disease (ESLD): A Cluster Randomized Controlled Trial
Other Drug/Treatment Evaluations
Pediatric
Cardiology
- Kids MoD PAH Trial: Mono- vs. Duo-Therapy for Pediatric Pulmonary Arterial Hypertension
Pharmacokinetics
- CUDDLE: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
- POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children per Standard of Care
Rheumatology
- CARRA Registry: Observational Study of Pediatric Rheumatic Diseases
Surgery
- ANA: Anesthetics and Analgesics in Children
Respiratory
- IPF-PRO/ILD-PRO Registry: Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) and Interstitial Lung Disease Prospective Outcomes (ILD-PRO) Registry
- TBS02: A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults with Asthma