Collaboration among research sites, community partners, patients, their caregivers, and our study teams is critical to addressing current medical care challenges. We work with institutions around the world that are equally committed to safe, inclusive, and efficient clinical research.
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During the following episodes of DCRI's Beyond the Endpoint podcast, a stage 4 ocular melanoma patient shares how clinical trials saved her life, and a research practice manager at the Duke Heart Center shares her insights from working with clinical trial participants.
Ep. 7 | Stepping Up: Why Participate in Clinical Research?
In this episode of Beyond the Endpoint, hosts Manesh Patel and Emily O'Brien are joined by Jenny Cook and Katie Ortman-Doble to discuss the importance of clinical research participation. Katie, a cancer survivor, shares her personal journey through clinical trials and the impact that research has had on her life.
Ep. 8 | Stepping Up: From Curiosity to Confidence — What to Know Before You Join a Trial
Manesh Patel speaks with Krista Camuglia, a research practice manager at Duke Heart Center Clinical Research Unit, who shares her insights from working with clinical trial participants. The discussion addresses common misconceptions and concerns, and emphasizes the rigorous vetting process that ensures participant safety.
- Clinical Trials at Duke website: clinical trials available through Duke Health.
- ClinicalTrials.gov: a database of privately and publicly funded clinical studies conducted around the world.
- ResearchMatch: a free, secure registry developed by major academic institutions across the country.
- Duke Research Volunteer Registry: sign up to be notified of future studies you may be eligible for based on the information you provide.
The DCRI is a trusted partner across the U.S., Canada, and globally, with approximately 1,100 research sites throughout North America. Our clinical faculty maintain extensive personal relationships, while our strong connections with academic groups worldwide enable us to identify national leaders and high-performing sites overseas.
Potential site partners and investigators may use our site contact form to discuss collaboration.
We have provided a list of current opportunities for research partners and participants to engage with the DCRI, organized by therapeutic topic below. By clicking on the study name, you can learn more about each opportunity.
Cardiology
Atherosclerotic Cardiovascular Disease (ASCVD)
- Test 2 Treat: Implementation trial to improve LDL-C management after hospitalization for ASCVD
- V-INCLUSION: Evaluating inclisiran for LDL-C management in ASCVD and ASCVD risk equivalent populations
Cardiovascular Disease
- ARTEMIS: Study examining ziltivekimab vs. placebo in people with a heart attack
- IMPROVE-AD: Study focused on improving outcomes in aortic dissection
- PREVENTABLE: Pragmatic evaluation of events and benefits of lipid-lowering in older adults
Heart Failure
- BALANCED-HF: Phase III study evaluating balcinrenone/dapagliflozin vs. dapagliflozin on heart failure events and cardiovascular death in patients with heart failure and impaired kidney function
- COMET-HF: Trial assessing efficacy and safety of omecamtiv mecarbil in patients with symptomatic heart failure with severely reduced ejection fraction
Kidney Disease
- POSIBIL6: Dose-finding and CV outcomes study with CSL300 (clazakizumab) in adult subjects with end-stage kidney disease (ESKD) undergoing dialysis
COVID-19
- RECOVER-AUTONOMIC: Platform protocol evaluating interventions for autonomic dysfunction in post-acute sequelae of SARS-CoV-2 infection
- RECOVER-SLEEP: Platform protocol evaluating interventions for sleep disturbances in post-acute sequelae of SARS-CoV-2 infection
Pediatric
Pharmacokinetics
- CUDDLE: Study of pharmacokinetics and safety of commonly used drugs in lactating women and breastfed infants
- POP02: Study of pharmacokinetics, pharmacodynamics, and safety profile of understudied drugs administered to children per standard of care
Rheumatology
- CARRA Registry: Observational study of pediatric rheumatic diseases
Surgery
- ANA: Study of anesthetics and analgesics in children
Respiratory
- IPF-PRO/ILD-PRO Registry: Registry for idiopathic pulmonary fibrosis and interstitial lung disease Prospective Outcomes
- TBS02: Prospective, blinded, crossover trial of the exposure-response relationship of terbutaline sulfate in adults with asthma