A Society for Clinical Trial's 45th Annual Meeting Pre-Conference Workshop
This workshop is designed for those who wish to learn practical ways to design trials with hierarchical endpoints. We will provide a tutorial starting from the introduction to hierarchical endpoints and existing population win measures for hierarchical endpoints, starting with a single endpoint to hierarchical endpoints involving multiple mixed-type endpoints. An overview of estimation and inference approaches for unmatched and matched scenarios is provided, along with using the existing R packages to illustrate the analysis and design approaches with hands-on examples.