Study Shows Alarming Rise in Heart Failure Deaths, Especially Among Younger Adults
After decades of decline, heart failure mortality is climbing, with a dramatic rise in heart failure deaths among younger adults. The number of people dying from heart failure in the United States went down steadily from 1999 to 2009. However, progress made in treating heart failure began unraveling from 2009 to 2012 when heart failure-related mortality rates plateaued, according to a study led by Duke University School of Medicine.
Antibiotic Shows Effectiveness Against Deadly Staph Infections
An antibiotic that has shown effectiveness for bacterial pneumonia also appears successful in fighting methicillin-resistant staph infections, reports a team led by Duke Health. The drug, ceftobiprole, showed similar benefit when tested against the antibiotic daptomycin to treat complicated Staphylococcus aureus bacterial infections. If approved by the FDA, ceftobiprole could provide another line of defense against a common and often deadly bacterial infection.
ACTIV-6 trials show no benefit to fluticasone furoate for COVID-19 symptoms
A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no clinical benefit to taking fluticasone furoate for treatment of mild-to-moderate COVID-19 symptoms.
Study Confirms No Benefit to Taking Fluvoxamine for COVID-19 Symptoms
A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit to taking the antidepressant fluvoxamine at a dosage of 100 mg twice daily for 13 days for the treatment of mild-to-moderate COVID-19 symptoms.
Intravenous Iron Treatment Provides Some Benefit to Patients with Heart Failure and Iron Deficiency
Despite numerical improvements in mortality, hospitalizations and exercise ability, data did not reach the pre-specified level of statistical significance.
Newly published research explores impact of COVID-19 on hospitalized infants
Newly published research led by the Pediatrix Medical Group and the Duke Clinical Research Institute’s Rachel Greenberg, MD, MB, MHS assessed the impact of COVID-19 on pregnant women and infants admitted to the neonatal intensive care unit (NICU). It is believed to be the largest study evaluating the prevalence of COVID-19 within a diverse neonatal population and associated hospital outcomes.
ABC Science Collaborative, RADx-UP publish lessons learned about keeping children safe in school during COVID-19 pandemic
The ABC Science Collaborative and RADx-UP have published a special supplement to the research journal Pediatrics focused on lessons learned while navigating the K-12 school environment during the pandemic.
Early Dexamethasone Administration Can Reduce Death or Discharge to Hospice Among Certain Types Of COVID-19 Patients, DCRI Study Shows
Results from a Duke Clinical Research Institute study that were recently published in JAMA Network Open expand the depth of understanding of how dexamethasone can improve outcomes among patients ho
Intervention Helps Clinicians Meet Guidelines for Prescribing Diabetes, Heart Drugs
Patients who have diabetes and heart disease do best when both conditions are treated according to established guidelines, but far too many are not prescribed the effective therapies. A recent study — designed and led by the Duke Clinical Research Institute (DCRI) and an academic steering committee — found that a coordinated care approach between cardiologists and diabetes specialists resulted in more patients receiving the recommended therapies. The study was funded by Boehringer Ingelheim and Eli Lilly and Company.
EMPA-KIDNEY Trial shows benefits for CKD in broad range of patients
A recent trial of empagliflozin expanded the understanding of how the drug can slow chronic kidney disease in a wide range of patients, lowering the risk of disease progression and death from cardi