News Archive

If you want to change patient and provider behavior to improve a patient’s health, will an informational mailer make a difference?

A large randomized, placebo-controlled clinical trial led by the National Institutes of Health with support from the Duke Clinical Research Institute shows that treating adults hospitalized with COVID-19 with infliximab or abatacept – drugs widely used to treat certain autoimmune diseases – substantially improved clinical status and reduced deaths.

A recent paper from Duke Clinical Research Institute (DCRI) faculty on behalf of the American Gastroenterological Association (AGA) provides new tools for health care providers treating patients wi

As the Duke Clinical Research Institute (DCRI) celebrates Clinical Trials Day and we progress into the third year of the COVID-19 pandemic, we

A new study set out to determine the prevalence of tPA declination in a nationwide registry of acute ischemic stroke (AIS) patients and to investigate differences in declination by race-ethnicity. The results appear in a paper in the February 28 issue of Neurology entitled ‘Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke.’

A recent publication reports on an analysis of how study-specific fitness-for-use was addressed amongst pragmatic clinical trials that utilize real-world data (RWD), and makes recommendations to de

An industry emphasis on improving inclusion and diversity in clinical trials continues to grow, but strategies to achieve more balanced representation in research and clinical care remain elusive.

The DCRI celebrates its faculty members who recently received prestigious honors as part of Duke Medical School’s 2022 annual awards.

The goal of the Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF; NCT02901184) is to assess the potential efficacy of mineralocorticoid receptor antagonists in these patients, and to evaluate the feasibility of the pragmatic trial concept for a chronic HF intervention. This is the first registry-based randomized clinical trial (RRCT) in heart failure, and among the first to focus on a chronic health condition.

COVID-19 health care workers experienced high rates of potential moral injury that are comparable to rates among military veterans, according to a collaborative study between Duke University, Vanderbilt University, and the Department of Veterans Affairs (VA).