DCRI Think Tank Outlines Opportunities to Improve Drug Development for Kidney Disease
A wide range of stakeholders who attended an April 2019 DCRI Think Tank helped to identify current challenges to developing treatments for chronic kidney disease, as well as make recommendations for strategies to address these challenges.
CARRA Registry Fills Gap in Pediatric Rheumatology
Since its inception in 2015, the CARRA Registry, for which the DCRI serves as the coordinating center, has provided necessary infrastructure and data to support a wide range of clinical research projects.
Reliance on Observational Data Could Hinder Discovery of Evidence-Based Treatments
Even in the midst of a global pandemic, taking the time to conduct randomized controlled trials is the most rigorous way to build evidence for potential treatments, according to a recent opinion pi
Combining Randomization with Real-World Data to Move Research Forward
As the proliferation of real-world data continues, it is important to refocus on combining randomized trials with real-world data sources rather than relying on observations or common sense, write
Duke and Local School Districts Partner to Make Data-Driven Decisions on Schooling During COVID-19
A multi-disciplinary scientific advisory board will provide rapid readouts of data on epidemiology, infection transmission rates, and other research. The pilot project, which is funded by the NIH, creates a model with potential to expand to additional school districts across the nation.
DCRI Think Tank Paper Looks to Future of Pragmatic Clinical Trials
Attendees to a January 2019 DCRI Think Tank outlined recommendations for optimizing pragmatic clinical trials and weighing risks and benefits of innovative trial designs.
Cath Lab Activation Time an Important Quality Metric for Patients with STEMI Presenting in non-PCI Capable Hospitals
An analysis of a study called Mission: Lifeline STEMI Accelerator II found that when patients experiencing an ST-elevation myocardial infarction present in facilities not capable of performing percutaneous intervention, the time between their arrival and cath lab activation is an important quality metric to direct timely reperfusion.
Challenges to Developing and Implementing Integrated Pain Management Programs
DCRI faculty recently contributed to a paper advocating for a focus on pain management so that progress in combatting the U.S. opioid crisis is not lost in the midst of the COVID-19 pandemic.
Splanchnic Nerve Block Effective for Improving Exercise Measures in Patients with Heart Failure
Study results recently published in the Journal of the American College of Cardiology: Heart Failure build on novel research investigating the efficacy of blocking the splanchnic nerve to treat patients with heart failure. The study, which was led by former DCRI fellow Marat Fudim, MD, MHS, included 15 patients who underwent a temporary medication-induced splanchnic nerve blockage and required them to complete an exercise twice—once prior to the blockage, and once after the blockage.
DCRI Study Provides Insight into Re-operation After Transcatheter Valve Replacement
Although valve failure is rare, patients who had to undergo re-operation were at risk of negative outcomes.