New DCRI Registry Could Provide Path for Pediatric Migraine Drug Development
A recently published paper details the development and design of the FDA-funded Pediatric Migraine Registry, which has enrolled around 200 patients between the ages of 4 and 17.
Interventional Cardiologists Must Stay Up-to-date on Training to Avoid ‘Proficiency Divide’
The DCRI’s Sunil Rao, MD, writes that to deliver high quality care, interventional cardiologists must constantly evaluate their practice and learn new techniques and skills.
DCRI and Digital Solutions: A New World of Evidence Generation
From thought leadership on a national stage to driving adoption for digital health technologies, the DCRI is leading the way in the digital therapeutic space.
Special Considerations for Resuscitation of Older Patients
Resuscitation after out-of-hospital cardiac arrest should not be administered using a one-size-fits-all approach, especially when treating older patients, according to an editorial in
UPDATE: DCRI Researchers Discuss Recruitment Challenges for Coronavirus Trials
The DCRI’s Michael Pencina, PhD, and Sheng Luo, PhD, discussed the design of two new Phase 3 clinical trials testing a potential treatment for coronavirus.
System-Wide Change Needed to Conduct More Randomized Clinical Trials at Lower Cost
A focus on building a nationwide system of real-world data could provide the opportunity for more randomized clinical trials to generate needed evidence to inform health care decisions.
Abnormal Electrocardiography Despite Normal Stress Echocardiography Could be Warning Sign
Findings from a DCRI-led study recently published in JAMA Internal Medicine suggest new prognostic implications for patients who have abnormal exercise electrocardiography (ECG) but normal stress echocardiography (Echo) results.
In clinical practice, exercise ECG is combined with stress Echo imaging for the evaluation of coronary artery disease. Although it is not uncommon for patients to have discordant results (abnormal ECGs and normal Echos), it was previously unclear whether this had any prognostic significance for these patients. An observational study led by DCRI’s Melissa Daubert, MD, sought to answer this question.
Approval Rates for PCSK9 Inhibitors Remain Low Even After Positive Trial Results
Neither prescription volume nor approval rates for PCSK9 inhibitors increased following the release of results from two large outcomes trials that demonstrated safety and effectiveness of this nove
Improvements Needed for Assessing Treatment Effectiveness Using Real-World Data
In a recent editorial, DCRI faculty call for improved heart failure trial enrollment, as well as modifications to the infrastructure used to evaluate whether treatments work in real-world settings.
Longitudinal Study Links Variable Blood Pressure in Young Adults to Increased Risk for Cardiovascular Disease
Two DCRI researchers contributed to a study that points to a potential early warning sign for increased risk of cardiovascular disease.