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A new study shows that a simplified two-dose antibiotic treatment may be just as effective as traditional long-term IV therapy for serious staph (staphylococcus) bloodstream infections, offering patients a safer and easier path to recovery.

A new Duke University School of Medicine study shows that teaching teens how to navigate their neighborhoods – by bus, bike or on foot – can give their health a boost. Durham Parks and Recreation, Durham teens, and pediatric experts at Duke developed a program called Going Places to help kids from underserved neighborhoods build the confidence and skills to get around their city.

A recent study, led by Duke University researchers and published in the European Journ

Returning individual research results to clinical study participants has not historically been the norm, even for participants with abnormal findings. The paradigm, though, is shifting, with return of results becoming not only a scientific responsibility but also an ethical imperative. However, best practices haven’t been established yet. A team of Duke researchers led by Svati H. Shah, MD, MS, Ursula Geller Distinguished Professor of Research in Cardiovascular Diseases, and Neha Pagidipati, MD, MPH, associate professor of medicine, have developed a model using the Project Baseline Health Study (PBHS) for how to effectively communicate results to patients and help empower them towards their health and medical choices. The study also detailed the large number of abnormal results that were returned to participants, highlighting the need to consider these processes early in study design. Results were published in the American Journal of Medicine Open.

Five years after the start of the COVID-19 pandemic, the research community is reflecting on the historic research response to understand the disease and develop diagnostics, therapies, and vaccines. In a special thematic issue of the Journal of Clinical and Translational Science, a set of papers outlines the most critical takeaways for the public health and research communities that should be applied to future public health emergencies.

Leading experts recently explored how generative AI could revolutionize clinical research through automated documentation and enhanced trial efficiency. Their findings, published in JACC: Advances, outline crucial steps for successful AI integration while addressing technical, ethical, and regulatory challenges to ensure more inclusive and equitable research outcomes.

A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit in taking metformin at a titrated dosage of 1,500 mg per day for 14 days for the treatment of mild-to-moderate COVID-19 symptoms.

A new publication developed in collaboration by CTTI, the Duke Clinical Research Institute (DCRI), the Duke Margolis Institute for Health Policy, and Protas published in Trials highlights the current barriers to clinical trial transformation, areas of improvement, and actions needed to transform clinical evidence generation in the United States to better align with clinical care demands. A modern clinical trial infrastructure should prioritize trial accessibility, answer relevant study questions reliably, respond to public health emergencies rapidly, and more.

New evidence and results from eight studies based on data from the IPF-PRO/ILD-PRO Registry was shared by the Duke Clinical Research Institute (DCRI) and its collaborators at the American Tho

A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit in taking montelukast at a dosa