News Archive

A paper recently published in JAMA Cardiology details the design of ADAPTABLE, a DCRI-led pragmatic clinical trial that uses many novel elements to efficiently answer a question that has substantial impacts on public health. ADAPTABLE seeks to determine the optimal dose of aspirin for patients with heart disease. Although aspirin has been used as a secondary prevention method for nearly three decades, the question of whether low-dose or high-dose aspirin is more beneficial remains unanswered.

The study sought to simultaneously test a method for identifying individuals at high risk for Alzheimer’s disease while testing the efficacy of a potential treatment aimed at targets affecting cell

A report from an NIH Health Care Systems Research Collaboratory roundtable recently published in 

Although initial results from SECURE-PCI suggested that patients treated with periprocedural loading doses of atorvastatin and undergoing percutaneous coronary intervention (PCI) experienced a reduced risk of major adverse cardiovascular events (MACE), extended follow-up showed no significant difference. The 12-month results, which were recently published in JAMA, expand upon the initial study, which followed patients for 30 days.

From thought leadership on a national stage to driving adoption for digital health technologies, the DCRI is leading the way in the digital therapeutic space.

Resuscitation after out-of-hospital cardiac arrest should not be administered using a one-size-fits-all approach, especially when treating older patients, according to an editorial in 

Findings from a DCRI-led study recently published in JAMA Internal Medicine suggest new prognostic implications for patients who have abnormal exercise electrocardiography (ECG) but normal stress echocardiography (Echo) results. In clinical practice, exercise ECG is combined with stress Echo imaging for the evaluation of coronary artery disease. Although it is not uncommon for patients to have discordant results (abnormal ECGs and normal Echos), it was previously unclear whether this had any prognostic significance for these patients. An observational study led by DCRI’s Melissa Daubert, MD, sought to answer this question.

Two DCRI researchers contributed to a study that points to a potential early warning sign for increased risk of cardiovascular disease.

A recent study led by the DCRI leveraged real-world data to shed new light on resuscitation for patients on maintenance dialysis when they experience in-hospital cardiac arrest.

Evidence from a recently completed DCRI-led clinical trial supports the hypothesis that an investigational digital therapeutic may be an effective treatment for children with ADHD.