PRONOUNCE Trial Highlights Need for Rigorously Conducted Cardio-oncology Trials to Better Define Cardiovascular Risk of New Cancer Agents
The trial, which was terminated early due to slow enrollment and low number of events, did not conclusively show whether different modes of a common treatment for prostate cancer were associated wi
Different Paths, Similar Learnings from Two DCRI Virtual Trials
Research conducted remotely presents a number of benefits to clinical research—along with unique challenges.
Nationwide Clinical Study Expands Platform to Test Medications to Treat Mild-to-Moderate COVID-19
Web and phone-based enrollment allows people anywhere in the United States diagnosed with COVID-19 as outpatients to help test potential COVID-19 treatments without leaving home.
DCRI Think Tank Suggests Approach for Incorporating Patient-Reported Outcome Measures into Clinical Trials
A “validity argument” approach takes into account that the context of each trial is different and attempts to overcome barriers historically associated with measuring and reporting patient-reported
ABC Science Collaborative Finds Schools Are Safe, Even During COVID-19 Winter Surge; Transmission is Higher for Extracurricular Events Such as Sports
Despite a surge in community cases in winter 2020, within-school transmission remained low, with most transmission within high schools occurring in school-sponsored sports. New data analyzed and published by the DCRI-led ABC Science Collaborative sheds new light on school safety during a COVID-19 surge and reinforces the message that masking is an effective strategy to mitigate within-school transmission.
Increasing Health Care System Participation in Research Requires New Support Systems
DCRI Executive Director Adrian Hernandez, MD, MHS, and co-authors recently published a commentary in the New England Journal of Medicine advocating for new ways to incentivize health care systems t
Report Shows that N.C. K-12 Schools Reopened Safely, Paving the Way for Schools Nationwide to Limit COVID-19 Spread in the Classroom
Top scientists and physicians from the ABC Science Collaborative have shared insights from North Carolina schools, coupled with a science-based blueprint for all schools to resume full, in-person instruction safely. A new report issued today by the DCRI-led ABC Science Collaborative shows that North Carolina schools were highly successful in preventing the transmission of COVID-19 within school buildings and offers science-based learnings for the nation’s schools to limit COVID-19 spread.
DCRI and HumanFirst Collaborate to Improve Scientific Rigor for Digital Measures
The Duke Clinical Research Institute (DCRI) and HumanFirst announced today the creation of a new Digital Measures Evaluation Center for assessing sensors and other digital measures used in clinical research. HumanFirst, previously known as Elektra Labs, is a technology company leading the development of digital platforms to evaluate and enable the deployment of connected technologies in decentralized trials and virtual care.
Randomized, Pragmatic Trial Testing Antimicrobial Therapy for Treatment of Idiopathic Pulmonary Fibrosis Shows No Significant Effect
A large pragmatic study in idiopathic pulmonary fibrosis (IPF) found that antimicrobial therapy did not have a statistically significant effect on respiratory hospitalization or death compared with usual care alone.
What ADAPTABLE Has Taught Us
Following the presentation of results from DCRI’s ADAPTABLE