A Win-Win: DCRI study shows pulmonary rehab in COPD patients reduces health care costs while improving patient health
Pulmonary rehabilitation is an important evidenced-based treatment to improve health and quality of life for people living with Chronic Obstructive Pulmonary Disease (COPD). Now, new research from the Duke Clinical Research Institute has shown that the benefits of pulmonary rehabilitation are likely to extend beyond the patient to reduce costs for the health care system as well – with an estimated savings of more than $5,000 per patient.
Special Edition of Contemporary Clinical Trials Offers New Perspectives on Pragmatic and Virtual Clinical Trials
A special series of articles addressing pragmatic and virtual trials appears this week in the journal Contemporary Clinical Trials and offers practical approaches to the many challenges clinical trials face. The 14 articles bring together leaders, researchers, biostatisticians, and bioethicists—including members of the NIH Pragmatic Trials Collaboratory — who are rethinking key aspects of the development, conduct, and oversight of clinical trials.
IMPACT-AFib study shows a mailer not enough to increase blood thinner use in AF patients
If you want to change patient and provider behavior to improve a patient’s health, will an informational mailer make a difference?
Immune modulator drugs improved survival for people hospitalized with COVID-19
A large randomized, placebo-controlled clinical trial led by the National Institutes of Health with support from the Duke Clinical Research Institute shows that treating adults hospitalized with COVID-19 with infliximab or abatacept – drugs widely used to treat certain autoimmune diseases – substantially improved clinical status and reduced deaths.
DCRI faculty member develops H. pylori Quality Measure to Reduce Rates of Failed Eradication
A recent paper from Duke Clinical Research Institute (DCRI) faculty on behalf of the American Gastroenterological Association (AGA) provides new tools for health care providers treating patients wi
Thanking Research Partners and Participants During COVID-19 and Beyond
As the Duke Clinical Research Institute (DCRI) celebrates Clinical Trials Day and we progress into the third year of the COVID-19 pandemic, we
Stroke Patients’ Rates of Declining Thrombolysis Show Race-Ethnic Disparities
A new study set out to determine the prevalence of tPA declination in a nationwide registry of acute ischemic stroke (AIS) patients and to investigate differences in declination by race-ethnicity. The results appear in a paper in the February 28 issue of Neurology entitled ‘Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke.’
Evaluating Fitness-for-Use of Electronic Health Records in Pragmatic Clinical Trials
A recent publication reports on an analysis of how study-specific fitness-for-use was addressed amongst pragmatic clinical trials that utilize real-world data (RWD), and makes recommendations to de
DCRI Faculty Receive Duke School of Medicine Honors
The DCRI celebrates its faculty members who recently received prestigious honors as part of Duke Medical School’s 2022 annual awards.
Innovative Heart Failure Trial Infrastructure Serves as Model for Future Pragmatic Studies
The goal of the Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF; NCT02901184) is to assess the potential efficacy of mineralocorticoid receptor antagonists in these patients, and to evaluate the feasibility of the pragmatic trial concept for a chronic HF intervention. This is the first registry-based randomized clinical trial (RRCT) in heart failure, and among the first to focus on a chronic health condition.